Certain statins work better when taken with a meal. This is because the cholesterol-making enzyme is more active at night. Also, the half-life, or the amount of time it takes for half the dose to leave your body, of some statins is short. Simvastatin is an example of a statin that works better if taken in the evening.
Lovastatin should be taken with dinner. However, the extended-release version of lovastatin, Altoprev, should be taken at bedtime. Studies show that some of the newer statins can be just as effective when taken in the morning. HMG-CoA reductase inhibitors such as atorvastatin and rosuvastatin are more potent than older statins. They have half-lives of at least 14 hours. Follow directions carefully for maximum effectiveness. Your doctor knows your personal medical issues and is your best source for information.
Always ask if your statin should be taken with food or at a specific time of day. Statins work best when taken at the same time each day.
With some statins, drinking grapefruit juice, or eating grapefruit, is a bad idea. Grapefruit juice can cause that statin to stay in your body much longer, and the drug can build up. This can increase the risk of muscle breakdown, liver damage, and even kidney failure.
Statins can also interact with other medications, so tell your doctor about all the drugs you take. That includes supplements, over-the-counter medications, and prescription drugs. Statins can be effective in getting your cholesterol under control, but they come with risks. Some common side effects include muscle and joint aches, nausea, and headache. Crestor and Lipitor are used to reduce cholesterol. Crestor or Lipitor should be used, along with a diet low in saturated fat and cholesterol, when diet alone has not adequately worked to lower cholesterol.
They also increase HDL cholesterol, the good kind of cholesterol. Other indications are listed in the chart below. Crestor and Lipitor have not been studied in the treatment of Fredrickson Type I and V dyslipidemias. They looked at the effects of Lipitor, Crestor, Zocor , and Pravachol on lowering LDL low-density lipoprotein cholesterol after six weeks. The study concluded that Crestor lowered LDL cholesterol by 8.
Crestor also increased HDL cholesterol the good kind of cholesterol more than Lipitor did. All statins were similarly tolerated. Coronary atherosclerosis is a narrowing of blood vessels and buildup of calcium and fatty deposits in the arteries, making it harder for blood to get to the heart, and increasing the risk of coronary heart disease. The study also looked at safety and side effects. Although, it may be worth noting that AstraZeneca, manufacturer of Crestor, funded this study.
Also, these drugs were given at the highest doses, which is not as common in a clinical setting for the average patient. Both Crestor and Lipitor induced regression of atherosclerosis to a similar extent. Both drugs were well tolerated and had a low incidence of lab abnormalities. In a clinical setting, both drugs are widely prescribed and well-tolerated. The most effective medication for you can be determined by your healthcare provider, who can consider your medical conditions, history, and medications you take that could interact with Crestor or Lipitor.
Crestor or Lipitor are covered by most insurance and Medicare prescription plans in their generic forms of rosuvastatin or atorvastatin. Choosing the brand-name product will likely result in a higher copay or may not be covered.
Get the SingleCare prescription discount card. The most common side effects of Crestor are headache , muscle pain, abdominal pain, nausea, and weakness.
A rare but serious side effect of Crestor and Lipitor is myopathy muscle weakness and rhabdomyolysis the breakdown of muscle tissue, which can be very damaging. See the warnings section for more information. The occurrence of side effects may vary with dosage. This is not a full list of side effects. Other, serious side effects may occur. Talk to your healthcare provider about what side effects to expect from Crestor or Lipitor, and how to address them. An important reaction to know about Lipitor is that you should not drink an excess amount of grapefruit juice more than 1.
You could also ask your pharmacist for advice on other ways to help you remember to take your medicine. The amount of rosuvastatin that can lead to an overdose varies from person to person. Take the rosuvastatin packet or the leaflet inside it, plus any remaining medicine with you. Like all medicines, rosuvastatin can cause side effects, although not everyone gets them.
Side effects often improve as your body gets used to the medicine. One rare but serious side effect is unexplained muscle aches and pains , tenderness or weakness. This can happen a few weeks or months after you first start taking this medicine.
Report any unexplained muscle aches and pains, tenderness or weakness to a doctor straight away. Talk to your doctor or a pharmacist if side effects are bothering you. They may recommend trying an alternative statin. Keep taking the medicine, but tell your doctor or pharmacist if these side effects bother you or do not go away:. If you experience problems with your memory, speak to your doctor, as it may be unrelated to rosuvastatin. In rare cases, it's possible to have a serious allergic reaction anaphylaxis to rosuvastatin.
You could be having a serious allergic reaction and may need immediate treatment in hospital. You can report any suspected side effect to the UK safety scheme. Rosuvastatin is not recommended during pregnancy or breastfeeding, as there's no firm evidence it's safe. If you want to get pregnant, speak to your doctor. It's best to stop taking rosuvastatin at least 3 months before you start trying for a baby. If you become pregnant while taking rosuvastatin, stop taking the medicine and tell your doctor.
It's not known if rosuvastatin passes into breast milk, but it may cause problems for your baby. Speak to your doctor about what's best for you and your baby while you're breastfeeding. It may be possible to delay starting or restarting rosuvastatin until you have stopped breastfeeding completely. Some medicines and rosuvastatin can interfere with each other and increase the chances of you having side effects. If you're taking rosuvastatin and need to take one of these medicines, your doctor may lower your dose or prescribe a different statin.
If you need to take an antibiotic, your doctor might recommend you stop taking rosuvastatin for a while. For a full list, see the leaflet inside your medicine packet or check with your pharmacist. There's very little information about taking herbal remedies and supplements while you use rosuvastatin. For safety, tell your doctor and pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements. Rosuvastatin acts on the liver to stop it making cholesterol.
This lowers your cholesterol level. For the first 12 months on this medicine, you'll be offered some routine tests to make sure your liver is working normally. Rosuvastatin starts to work within a week to reduce cholesterol, but it can take up to a month to achieve its full effect. Usually you'll take rosuvastatin for life. The benefits will only continue for as long as you take it. If you stop taking rosuvastatin without starting a different treatment, your cholesterol level may rise again.
You may have read negative stories about statins, but they're thought to be very safe, effective medicines. Statins are thought to have very few side effects. Sometimes the side effects that people report are not related to their medicine. But if you're concerned about the safety of statins, talk to your doctor.
You may want to stop rosuvastatin if you think you're having side effects. Talk to your doctor first to see if it really is a side effect of rosuvastatin or an unrelated problem.
Your doctor may decide to lower your dose or change your medicine. You will not get any withdrawal symptoms. But stopping rosuvastatin may cause your cholesterol to rise. This increases your risk of heart attacks and strokes.
If you want to stop taking your medicine, it's important to find another way to lower your cholesterol.
Statins all work in the same way, but they differ in how well they lower cholesterol. When used at a higher dose, rosuvastatin and atorvastatin produce a bigger reduction in cholesterol than the other statins. If you have a side effect with one statin, it may not happen with another. Some medicines do not mix well with one statin, but are OK to take with other ones.
Your doctor will find the right statin and dose for you, depending on your medical history, cholesterol level and the other medicines you take. If you're at high risk of developing type 2 diabetes, taking statins may slightly increase this risk. Speak to your doctor, who will be able to explain how the benefits of taking statins are likely to outweigh this small increased risk. If you already have type 2 diabetes, your doctor may advise monitoring your blood sugar levels more closely for the first few months.
Tell your doctor or diabetes nurse if you find it harder to control your blood sugar. But there's no firm evidence that taking CoQ10 at the same time as rosuvastatin will benefit your health. More research is needed.
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