In genetics, dominance pertains to a gene or allele expressed over the other genes or alleles. There are three major forms: complete dominance , incomplete dominance , and codominance. When an individual inherited two dominant alleles e.
AA or inherits at least one dominant allele e. Aa , that individual will show the trait because of the presence of the dominant allele. In contrast, the individual lacking the dominant allele e. This is what occurs in the complete dominance and the resulting pattern conforms to the Mendelian inheritance.
Hence, the heterozygous organism Aa will have a trait similar to the homozygous dominant AA. Conversely, those that do not conform exemplify the non-Mendelian type of inheritance.
In non-Mendelian inheritance, the resulting phenotype of the offspring is different from the phenotypes of either parent. Codominance and incomplete dominance are examples. This results in offspring with a phenotype that is neither dominant nor recessive. As for the incomplete dominance definition, this form of inheritance occurs when the phenotype is intermediate to the phenotype of the parents. An example of incomplete dominance is when a male white flower parent is crossed with a female red flower the offspring will be a plant that will soon bear pink flowers.
Codominance is different from incomplete dominance in the way that the former has both alleles manifesting the phenotypes whereas the latter produces an intermediate phenotype. Got a question about codominance? Share with us what you think. It implies that both dominant alleles are present and expressed together.
This indicates type AB blood. Conversely, a genotype of ii means lacking such modifications on the H antigen and an indication of a type O blood. In codominance, blood type AB implies that both dominant alleles are present and expressed together. In other animals, codominance is exemplified by a mix of coat colors in a progeny of parents with different coat colors.
For example, a cross between a black-furred male dog and a white-furred female dog could produce offspring with a black-and-white coat. This means that the color coat traits of the parents are codominant as both were expressed together in the progeny.
Codominance is exemplified by a plant that bears flowers with two distinct color phenotypes. For instance, a white-spotted red flower could be caused by a cross between a red flower and a white flower. The alleles for the red and white color phenotypes mean that they are codominant. Take note that codominance is a different concept from polygenic inheritance. While both of them do not conform to the Mendelian inheritance, they differ in the way that in polygenic inheritance multiple genes are involved to produce cumulative effects.
Examples of polygenic traits in humans are height, weight, skin color, and eye color. Get in touch with our community. Be a part of us! Females must inherit recessive X-linked alleles from both of their parents in order to express the trait.
Color perception in different types of color blindness : In this chart you can see what people with different types of color blindness can see versus the normal color vision line at top. When they inherit one recessive X-linked mutant allele and one dominant X-linked wild-type allele, they are carriers of the trait and are typically unaffected.
Carrier females can manifest mild forms of the trait due to the inactivation of the dominant allele located on one of the X chromosomes. However, female carriers can contribute the trait to their sons, resulting in the son exhibiting the trait, or they can contribute the recessive allele to their daughters, resulting in the daughters being carriers of the trait.
Although some Y-linked recessive disorders exist, typically they are associated with infertility in males and are, therefore, not transmitted to subsequent generations. Inheritance of a recessive X-linked disorder : The son of a woman who is a carrier of a recessive X-linked disorder will have a 50 percent chance of being affected.
A daughter will not be affected, but she will have a 50 percent chance of being a carrier like her mother. Occasionally, a nonfunctional allele for an essential gene can arise by mutation and be transmitted in a population as long as individuals with this allele also have a wild-type, functional copy. The wild-type allele functions at a capacity sufficient to sustain life and is, therefore, considered to be dominant over the nonfunctional allele.
In one quarter of their offspring, we would expect to observe individuals that are homozygous recessive for the nonfunctional allele. Because the gene is essential, these individuals might fail to develop past fertilization, die in utero, or die later in life, depending on what life stage requires this gene.
An inheritance pattern in which an allele is only lethal in the homozygous form and in which the heterozygote may be normal or have some altered non-lethal phenotype is referred to as recessive lethal. For crosses between heterozygous individuals with a recessive lethal allele that causes death before birth when homozygous, only wild-type homozygotes and heterozygotes would be observed. The genotypic ratio would therefore be In other instances, the recessive lethal allele might also exhibit a dominant but not lethal phenotype in the heterozygote.
For instance, the recessive lethal Curly allele in Drosophila affects wing shape in the heterozygote form, but is lethal in the homozygote.
A single copy of the wild-type allele is not always sufficient for normal functioning or even survival. The dominant lethal inheritance pattern is one in which an allele is lethal both in the homozygote and the heterozygote; this allele can only be transmitted if the lethality phenotype occurs after reproductive age. Individuals with mutations that result in dominant lethal alleles fail to survive even in the heterozygote form. Dominant lethal alleles are very rare because, as you might expect, the allele only lasts one generation and is not transmitted.
However, just as the recessive lethal allele might not immediately manifest the phenotype of death, dominant lethal alleles also might not be expressed until adulthood. Once the individual reaches reproductive age, the allele may be unknowingly passed on, resulting in a delayed death in both generations.
People who are heterozygous for the dominant Huntington allele Hh will inevitably develop the fatal disease. Privacy Policy. Skip to main content. Search for:. Patterns of Inheritance. Genes as the Unit of Heredity Genes exist in pairs within an organism, with one of each pair inherited from each parent. Learning Objectives Describe the structure of a gene and how offspring inherit genes from each parent. Key Takeaways Key Points A gene is a stretch of DNA that helps to control the development and function of all organs and working systems in the body.
Genes are passed from parent to offspring; the combination of these genes affects all aspects of the human body, from eye and hair color to how well the liver can process toxins. A human will inherit 23 chromosomes from its mother and 23 from its father; together, these form 23 pairs of chromosomes that direct the inherited characteristics of the individual.
If the two copies of a gene inherited from each parent are the same, that individual is said to be homozygous for the gene; if the two copies inherited from each parent are different, that individual is said to be heterozygous for the gene.
Key Terms gene : a unit of heredity; the functional units of chromosomes that determine specific characteristics by coding for specific proteins chromosome : a structure in the cell nucleus that contains DNA, histone protein, and other structural proteins genetics : the branch of biology that deals with the transmission and variation of inherited characteristics, in particular chromosomes and DNA.
Phenotypes and Genotypes The observable traits expressed by an organism are referred to as its phenotype and its underlying genetic makeup is called its genotype. Learning Objectives Distinguish between the phenotype and the genotype of an organism.
Key Takeaways Key Points Mendel used pea plants with seven distinct traits or phenotypes to determine the pattern of inheritance and the underlying genotypes. Mendel found that crossing two purebred pea plants which expressed different traits resulted in an F 1 generation where all the pea plants expressed the same trait or phenotype. When Mendel allowed the F 1 plants to self-fertilize, the F 2 generation showed two different phenotypes, indicating that the F 1 plants had different genotypes.
The Punnett Square Approach for a Monohybrid Cross A Punnett square applies the rules of probability to predict the possible outcomes of a monohybrid cross and their expected frequencies. Learning Objectives Describe the Punnett square approach to a monohybrid cross. Key Takeaways Key Points Fertilization between two true-breeding parents that differ in only one characteristic is called a monohybrid cross.
For a monohybrid cross of two true-breeding parents, each parent contributes one type of allele resulting in all of the offspring with the same genotype. A test cross is a way to determine whether an organism that expressed a dominant trait was a heterozygote or a homozygote. Key Terms monohybrid : a hybrid between two species that only have a difference of one gene homozygous : of an organism in which both copies of a given gene have the same allele heterozygous : of an organism which has two different alleles of a given gene Punnett square : a graphical representation used to determine the probability of an offspring expressing a particular genotype.
Alternatives to Dominance and Recessiveness With the inclusion of incomplete dominance, codominance, multiple alleles, and mutant alleles, the inheritance of traits is complex process. Learning Objectives Discuss incomplete dominance, codominance, and multiple alleles as alternatives to dominance and recessiveness. Key Takeaways Key Points Incomplete dominance is the expression of two contrasting alleles such that the individual displays an intermediate phenotype. Codominance is a variation on incomplete dominance in which both alleles for the same characteristic are simultaneously expressed in the heterozygote.
Diploid organisms can only have two alleles for a given gene; however, multiple alleles may exist at the population level such that many combinations of two alleles are observed. One mutant allele can also be dominant over all other phenotypes, including the wild type. Key Terms allele : one of a number of alternative forms of the same gene occupying a given position on a chromosome incomplete dominance : a condition in which the phenotype of the heterozygous genotype is distinct from and often intermediate to the phenotypes of the homozygous genotypes codominance : a condition in which both alleles of a gene pair in a heterozygote are fully expressed, with neither one being dominant or recessive to the other.
Sex-Linked Traits A gene present on one of the sex chromosomes X or Y in mammals is a sex-linked trait because its expression depends on the sex of the individual. Learning Objectives Distinguish between sex-linked traits and other forms of inheritance. The Y chromosome contains a small region of similarity to the X chromosome so that they can pair during meiosis, but the Y is much shorter and contains fewer genes.
Males are said to be hemizygous because they have only one allele for any X-linked characteristic; males will exhibit the trait of any gene on the X-chromosome regardless of dominance and recessiveness. Most sex-linked traits are actually X-linked, such as eye color in Drosophila or color blindness in humans. Key Terms hemizygous : Having some single copies of genes in an otherwise diploid cell or organism.
X-linked : Associated with the X chromosome. Lethal Inheritance Patterns Inheriting two copies of mutated genes that are nonfunctional can have lethal consequences. Learning Objectives Describe recessive and dominant lethal inheritance patterns. Key Takeaways Key Points An inheritance pattern in which an allele is only lethal in the homozygous form and in which the heterozygote may be normal or have some altered non-lethal phenotype is referred to as recessive lethal.
Dominant lethal alleles are very rare because the allele only lasts one generation and is, therefore, not usually transmitted. In the case where dominant lethal alleles might not be expressed until adulthood, the allele may be unknowingly passed on, resulting in a delayed death in both generations. Key Terms mutation : any heritable change of the base-pair sequence of genetic material recessive lethal : an inheritance pattern in which an allele is only lethal in the homozygous form and in which the heterozygote may be normal or have some altered non-lethal phenotype dominant lethal : an inheritance pattern is one in which an allele is lethal both in the homozygote and the heterozygote; this allele can only be transmitted if the lethality phenotype occurs after reproductive age.
Parsons, P. The evolution of overdominance: Natural selection and heterozygote advantage. Nature , 7—12 link to article. Stratton, F. The human blood groups. Nature , link to article.
Chromosome Theory and the Castle and Morgan Debate. Discovery and Types of Genetic Linkage. Genetics and Statistical Analysis. Thomas Hunt Morgan and Sex Linkage. Developing the Chromosome Theory. Genetic Recombination. Gregor Mendel and the Principles of Inheritance. Mitosis, Meiosis, and Inheritance. Multifactorial Inheritance and Genetic Disease. Non-nuclear Genes and Their Inheritance. Polygenic Inheritance and Gene Mapping.
Sex Chromosomes and Sex Determination. Sex Determination in Honeybees. Test Crosses. Biological Complexity and Integrative Levels of Organization.
Genetics of Dog Breeding. Human Evolutionary Tree. Mendelian Ratios and Lethal Genes. Environmental Influences on Gene Expression. Epistasis: Gene Interaction and Phenotype Effects. Genetic Dominance: Genotype-Phenotype Relationships. Phenotype Variability: Penetrance and Expressivity. Citation: Miko, I.
Nature Education 1 1 Why can you possess traits neither of your parents have? The relationship of genotype to phenotype is rarely as simple as the dominant and recessive patterns described by Mendel. Aa Aa Aa. Complete versus Partial Dominance. Figure 1. Figure Detail. Multiple Alleles and Dominance Series. Summarizing the Role of Dominance and Recessivity. References and Recommended Reading Keeton, W.
Heredity 35 , 85—98 Parsons, P. Nature , 7—12 link to article Stratton, F. Article History Close. Share Cancel. Revoke Cancel. Keywords Keywords for this Article. Save Cancel.
Flag Inappropriate The Content is: Objectionable. Flag Content Cancel.
0コメント